Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

März, W; Grützmacher, P; Paul, D; Siekmeier, R; Schoeppe, W; Gross, W.
Effects of lovastatin (20-80 mg daily) on lipoprotein fractions in patients with severe primary hypercholesterolemia.
Int J Clin Pharmacol Ther. 1994; 32(2):92-97
Web of Science PubMed Google Scholar

Leading authors Med Uni Graz: März Winfried
Altmetrics:
Dimensions Citations:
Plum Analytics:
Abstract:: The effect of lovastatin on lipids, lipoproteins and apolipoproteins was studied in 10 patients with primary hypercholesterolemia. After four weeks diet/placebo alone, patients received diet plus lovastatin at daily doses of 20 mg (weeks 1-4), 40 mg (weeks 5-8) and 80 mg (weeks 9-12). Twelve weeks of treatment with lovastatin resulted in a lowering of total cholesterol and LDL-cholesterol by 34% and 41%, respectively. Triglycerides and VLDL-cholesterol decreased by 19% and by 42%, respectively. HDL-cholesterol and HDL2-cholesterol increased, whereas HDL3-cholesterol was not affected. IDL-cholesterol decreased by 50%, suggesting that the clearance of remnant lipoproteins was enhanced by lovastatin. In the VLDL and the IDL fraction, the triglyceride to cholesterol mass ratio increased significantly after twelve weeks of therapy. Lipoprotein(a) was not affected. Lovastatin was well tolerated and the data shows that lovastatin exerts favorable effects on plasma lipoprotein fractions. It may, therefore, prove a useful drug in the primary and secondary prevention of atherosclerotic vessel diseases.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Apolipoproteins - metabolism; Cholesterol - blood; Dose-Response Relationship, Drug - blood; Female - blood; Humans - blood; Hypercholesterolemia - diet therapy; Lipoproteins - blood; Lovastatin - administration and dosage; Male - administration and dosage; Middle Aged - administration and dosage; Triglycerides - blood
Find related publications in this database (Keywords): CHOLESTEROL; TRIGLYCERIDES; VLDL; IDL; LDL; HDL; HDL SUBFRACTIONS; LOVASTATIN; LIPOPROTEIN (A)