Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kullmer, T; Kneissl, G; Katova, T; Kronenberger, H; Urhausen, A; Kindermann, W; März, W; Meier-Sydow, J.
Experimental acute hypoxia in healthy subjects: evaluation of systolic and diastolic function of the left ventricle at rest and during exercise using echocardiography.
Eur J Appl Physiol Occup Physiol. 1995; 70(2):169-174
Doi: 10.1007/BF00361545
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- To clarify whether or not systolic and diastolic function of the human left ventricle (LV) were decreased during acute hypoxia, at rest and with exercise, 14 healthy male volunteers [age 25.9 (SD 3.0) years, height 182.9 (SD 7.1) cm, body mass 75.9 (SD 6.9)kg] were examined using M-mode and 2D-mode echocardiography to determine the systolic LV function as well as Doppler-echocardiography for the assessment of diastolic LV function on 2 separate test days. In random order, the subjects breathed either air on 1 day (N) or a gas mixture with reduced oxygen content on the other (H; oxygen fraction in inspired gas 0.14). Measurements on either day were made at rest, several times during incremental cycle exercise in a supine position (6-min increments of 50 W, maximal load 150 W) and in 6th min of recovery. Corresponding measurements during N and H were compared statistically. Arterial O2 tension (PaO2) was normal on N-day. All subjects showed a marked acute hypoxia at rest [PaO2, 54.5 (SD 4.6) mmHg], during exercise and recovery on H-day. The latter was associated with tachycardia compared to N-day. All echocardiographic measurements at rest were within the limits of normal values on both test days. Ejection time, end-systolic and end-diastolic left ventricular dimensions as well as the thickness of left posterior wall and of interventricular septum showed no statistically significant influence of H either at rest or during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anoxia - physiopathology
- Cardiac Output - physiology
- Diastole - physiology
- Echocardiography, Doppler - physiology
- Exercise - physiology
- Humans - physiology
- Male - physiology
- Oxygen Consumption - physiology
- Rest - physiology
- Single-Blind Method - physiology
- Stroke Volume - physiology
- Systole - physiology
- Ventricular Function, Left - physiology
- Find related publications in this database (Keywords)
- ACUTE ARTERIAL HYPOXIA
- ECHOCARDIOGRAPHY
- LEFT VENTRICLE
- DOPPLER ECHOCARDIOGRAPHY