Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kuhl, H; Jung-Hoffmann, C; Fitzner, M; März, W; Gross, W.
Short- and long-term effects on lipid metabolism of oral contraceptives containing 30 micrograms ethinylestradiol and 150 micrograms desogestrel or 3-keto-desogestrel.
Horm Res. 1995; 44(3): 121-125.
Doi: 10.1159/000184610
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- During a cross-over study with young female volunteers, the effects of a combination of 30 micrograms ethinylestradiol (EE) and 150 micrograms desogestrel (DG) or 3-keto-desogestrel (KDG) upon lipid metabolism were investigated on day 3 of the first cycle (day 3/I) and on day 21 of the third cycle of treatment (day 21/III). As compared to the control cycle, total cholesterol (CH), low-density lipoprotein CH (LDL-CH), and the apolipoproteins A-II and B were reduced already on day 3/I, the effects being more pronounced with the DG-containing formulation. On day 21/III of treatment with EE/DG, the levels of total CH, LDL-CH and apolipoprotein B did not differ from controls, while apolipoprotein A-II was significantly increased. The effects of EE/KDG were similar, except that on LDL-CH which was still reduced on day 21/III. The serum concentrations of total triglycerides (TG), very low-density lipoprotein CH (VLDL-CH), VLDL-TG, LD-TG, high-density lipoprotein CH (HDL-CH), HDL-TG, and apolipoprotein A-I were not significantly affected on day 3/I, but elevated on day 21/III. As during treatment with EE/KDG the peak level of KDG was higher than with EE/DG, the results indicate a more pronounced antagonistic effect of EE/KDG on some EE-induced changes on lipoproteins during the first days of intake. These short-term changes possibly reflect a rapid enhancement of hepatic uptake of remnants and LDL by EE. During long-term treatment, the other effects of EE, e.g. the stimulation of hepatic synthesis of TG, VLDL, and HDL and the inhibition of hepatic lipoprotein lipase, become apparent.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apolipoprotein A-I - blood
- Cholesterol - blood
- Contraceptives, Oral, Hormonal - adverse effects
- Cross-Over Studies - adverse effects
- Desogestrel - adverse effects
- Estradiol Congeners - adverse effects
- Ethinyl Estradiol - adverse effects
- Female - adverse effects
- Humans - adverse effects
- Lipid Metabolism - adverse effects
- Lipoproteins, HDL - blood
- Lipoproteins, LDL - blood
- Progesterone Congeners - adverse effects
- Triglycerides - blood
- Find related publications in this database (Keywords)
- ORAL CONTRACEPTIVES
- ETHINYLESTRADIOL
- DESOGESTREL
- 3-KETO-DESOGESTREL
- LIPID METABOLISM
- LIPOPROTEINS