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Selected Publication:
Krämer-Guth, A; Quaschning, T; Galle, J; Baumstark, MW; Königer, M; Nauck, M; Schollmeyer, P; März, W; Wanner, C.
Structural and compositional modifications of diabetic low-density lipoproteins influence their receptor-mediated uptake by hepatocytes.
Eur J Clin Invest. 1997; 27(6):460-468
Doi: 10.1046/j.1365-2362.1997.1460695.x
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- Co-authors Med Uni Graz
- März Winfried
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- Abstract:
- Dyslipoproteinaemia is an important risk factor for the development of atherosclerosis in noninsulin-dependent diabetes mellitus (NIDDM). This study shows that the uptake of low-density lipoproteins (LDLs) prepared from the plasma of patients with NIDDM in cultured human hepatoma cells is largely reduced. In addition, diabetic LDL was less effective in suppressing intracellular cholesterol synthesis. This is because of physicochemical and biochemical differences between lipoproteins from diabetic and from normal individuals. LDL from patients with NIDDM was abnormal with regard to charge, the degree of glycation, the lipid composition and the conformation of the apolipoprotein B receptor-binding domain. The diminished receptor-mediated uptake of apolipoprotein B-containing lipoproteins in diabetic individuals most probably leads to the accumulation of these lipoproteins in vivo and may be of great importance to the pathogenesis of atheroclerosis in these patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetic Acid - metabolism
- Aged - metabolism
- Arteriosclerosis - etiology
- Biological Transport, Active - etiology
- Cell Line - etiology
- Cholesterol Esters - biosynthesis
- Diabetes Mellitus, Type 2 - blood
- Diabetic Angiopathies - etiology
- Female - etiology
- Glycosylation - etiology
- Humans - etiology
- Lipoproteins, LDL - blood
- Liver - metabolism
- Male - metabolism
- Middle Aged - metabolism
- Oleic Acid - metabolism
- Oxidation-Reduction - metabolism
- Protein Conformation - metabolism
- Receptors, LDL - metabolism
- Sterols - biosynthesis
- Find related publications in this database (Keywords)
- atherosclerosis
- glycation
- modified low-density lipoprotein
- low-density lipoprotein subfractions
- low-density lipoprotein receptor