Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Braun, J; März, W; Winkelmann, BR; Donner, H; Henning Usadel, K; Badenhoop, K.
Tumour necrosis factor beta alleles and hyperinsulinaemia in coronary artery disease.
Eur J Clin Invest. 1998; 28(7):538-542
Doi: 10.1046/j.1365-2362.1998.00334.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- BACKGROUND: Hyperinsulinaemia and dyslipoproteinaemia are markers and risk factors for coronary artery disease (CAD) and non-insulin-dependent diabetes mellitus (NIDDM). We investigated the influence of a tumour necrosis factor beta (TNF-beta) gene polymorphism on serum parameters related to these metabolic disorders in patients with CAD. METHODS: A total of 199 patients with CAD and 81 control subjects with angiographically normal coronary arteries were studied. A digestion of amplified DNA with NcoI revealed three fragment patterns: homozygosity for TNF-beta *1 or TNF-beta *2 and heterozygosity (TNF-beta *1/*2). RESULTS: Patients with CAD who had increased serum insulin or C-peptide (fasting and after glucose load) were predominantly heterozygous for TNF-beta (72% vs. 47%) and less frequently homozygous for TNF-beta *2 (22% vs. 43%, P = 0 x 0.03). CONCLUSION: This study demonstrates an association of TNF-beta alleles with the risk factor hyperinsulinaemia in CAD. Genomic variants of TNF-beta may therefore contribute to the complex susceptibility for the metabolic syndrome in patients with CAD.
- Find related publications in this database (using NLM MeSH Indexing)
- Alleles -
- C-Peptide - blood
- Coronary Disease - blood
- Gene Frequency - blood
- Glucose Tolerance Test - blood
- Heart Valve Diseases - genetics
- Heterozygote - genetics
- Homozygote - genetics
- Humans - genetics
- Hyperinsulinism - blood
- Insulin - blood
- Lymphotoxin-alpha - genetics
- Male - genetics
- Middle Aged - genetics
- Polymorphism, Genetic - genetics
- Find related publications in this database (Keywords)
- coronary artery disease
- gene polymorphism
- hyperinsulinaemia
- non-insulin-dependent diabetes
- tumour necrosis factor beta