Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nauck, MS; Nauck, MA; Nauck, MA; März, W; Wieland, H.
Six methods for the determination of C-peptide evaluated.
Clin Chem Lab Med. 1999; 37(7):745-751
Doi: 10.1515/CCLM.1999.115
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Six assays for C-peptide were evaluated. Five assays were radioimmunoassays; one was a chemiluminescence assay. The within-run coefficient of variation ranged between 2.1 and 22.9%. The methods correlated well with each other (r = 0.925 to 0.978). There were, however, proportional biases between the assays, in particular in the higher concentration range. All assays were linear up to at least 4.5 ng/ml C-peptide concentration. All assays were easy to perform. However, the systematic bias between the assays demonstrates that further effort is needed to standardize the measurement of C-peptide. In the mean-time, we recommend that laboratories conducting C-peptide measurements establish local, method-specific reference ranges.
- Find related publications in this database (using NLM MeSH Indexing)
- C-Peptide - blood
- Chemiluminescent Measurements - blood
- Female - blood
- Humans - blood
- Immunoassay - methods
- Male - methods
- Radioimmunoassay - methods
- Find related publications in this database (Keywords)
- C-peptide
- radio immunoassay
- chemiluminescence immunoassay