Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Larson, I; Hoffmann, MM; Ordovas, JM; Schaefer, EJ; März, W; Kreuzer, J.
The lipoprotein lipase HindIII polymorphism: association with total cholesterol and LDL-cholesterol, but not with HDL and triglycerides in 342 females.
Clin Chem. 1999; 45(7):963-968
Doi: 10.1093/clinchem/45.7.963
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- BACKGROUND: Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of core triglycerides in chylomicrons and VLDL. METHODS: We investigated the association between the HindIII polymorphism of the LPL gene and fasting glucose, lipid, and lipoprotein concentrations in 683 Caucasians. We first stabilized the study subjects, using an 8-day diet and exercise intervention program before obtaining blood samples. The use of this standardization period reduced the variance of all glucose and lipid concentrations. RESULTS: In our study, the HindIII allele frequencies for females and males were 0.29 and 0.34 for H- and 0.71 and 0.66 for H+, respectively. We found in females, but not in males, a significant association between the HindIII genotype and total cholesterol (P = 0.007) and LDL-cholesterol (P = 0.018), with females homozygous for the rare H- allele having the lowest, heterozygotes (H-/+) having intermediate, and women homozygous for the common H+ allele having the highest of each of these lipid traits. With regard to triglycerides, HDL-cholesterol, and glucose, no significant effect of the HindIII genotype was noted in either gender. CONCLUSIONS: These results suggest that in a gender-specific manner, the rare LPL HindIII H- allele has a cholesterol-lowering and, therefore, potentially cardioprotective effect compared with the common H+ allele.
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- Alleles -
- Cholesterol - blood
- Cholesterol, HDL - blood
- Cholesterol, LDL - blood
- Deoxyribonuclease HindIII - blood
- Diet - blood
- Exercise - blood
- Female - blood
- Humans - blood
- Lipoprotein Lipase - genetics
- Male - genetics
- Middle Aged - genetics
- Phenotype - genetics
- Polymorphism, Restriction Fragment Length - genetics
- Sex Factors - genetics
- Triglycerides - blood