Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Winkler, K; Schäfer, JR; Klima, B; Nuber, C; Sattler, A; Friedrich, I; Köster, W; Steinmetz, A; Wieland, H; März, W.
Lifibrol enhances the low density lipoprotein apolipoprotein B-100 turnover in patients with hypercholesterolemia and mixed hyperlipidemia.
Atherosclerosis. 1999; 144(1):167-175
Doi: 10.1016/S0021-9150(99)00051-9
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Lifibrol (4-(4'-tert-butylphenyl)-1-(4'carboxyphenoxy)-2-butanol), a new hypocholesterolemic drug, effectively reduces total cholesterol (CH), low density lipoprotein (LDL)-CH, and apolipoprotein (apo) B in experimental animals and in humans. The impact of Lifibrol on the metabolism of apoB-100 containing lipoproteins in patients with hyperlipoproteinemia using endogenous labeling with stable isotopes is examined. Kinetic studies were performed in four male hypercholesterolemic individuals (type IIa) before and on treatment with 450 mg of Lifibrol daily for 4 weeks, and in five male individuals suffering from mixed hyperlipidemia (type IIb) before and on therapy for 12 weeks. Kinetic parameters were estimated by multicompartmental modeling. Lifibrol therapy reduced total CH by 16% (P = 0.012) in all patients, increased triglycerides (TG) by 11% (not significant) in type IIa patients and decreased TG by 34% (P = 0.059) in type IIb patients. During Lifibrol therapy, LDL apoB-100 concentrations decreased by 19% (P = 0.011) in all patients. The decrease in LDL apoB concentrations with Lifibrol therapy was due to an overall increase (75%, P = 0.006) of the fractional catabolic rates (FCR) of LDL apoB. This increase was partially attenuated by a 33% increase in LDL apoB production rate (PR) (P = 0.041). The overall production of apoB increased only slightly. Our data suggest that the major mechanism by which Lifibrol lowers LDL-CH is an increase in receptor-mediated catabolism of LDL rather than a decrease in hepatic apoB production.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticholesteremic Agents - administration and dosage
- Apolipoproteins B - drug effects
- Butanols - administration and dosage
- Female - administration and dosage
- Gas Chromatography-Mass Spectrometry - administration and dosage
- Humans - administration and dosage
- Hydroxybenzoic Acids - administration and dosage
- Hypercholesterolemia - complications
- Hyperlipidemias - complications
- Lipoproteins, LDL - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Statistics, Nonparametric - drug effects
- Treatment Outcome - drug effects
- Find related publications in this database (Keywords)
- cholesterol-lowering drugs
- in vivo kinetics
- stable isotopes
- LDL-receptor