Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nauck, M; Winkelmann, BR; Hoffmann, MM; Böhm, BO; Wieland, H; März, W.
The interleukin-6 G(-174)C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction.
J Mol Med. 2002; 80(8):507-513
Doi: 10.1007/s00109-002-0354-2
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- IL-6 plasma levels are predictive of major cardiovascular events. Recently a G/C polymorphism at position -174 in the promoter of the IL-6 gene has been associated with differences in both the IL-6 transcription rate in vitro and IL-6 levels in vivo. We examined the association of this polymorphism with coronary artery disease (CAD) and previous myocardial infarction (MI) in 2559 patients with angiographically documented CAD with ( n=1365) and without ( n=1194) MI and in a control group of 729 individuals in whom CAD had been ruled out angiographically. Assuming dominant or recessive modes of inheritance, carriers of the G allele had odds ratios of 0.98 (95% CI 0.79 - 1.20) and 0.96 (95% CI 0.80 - 1.14), respectively, for CAD, and almost identical ones for previous MI. In subgroups stratified for low cardiovascular risk, the IL-6 promoter polymorphism was also not related to the risk of CAD or MI. In addition, the plasma concentration of IL-6 did not differ between groups with different IL-6 genotypes in 942 randomly selected individuals. We conclude that the IL-6 G(-174)C polymorphism is not associated with the risk of CAD or MI and does not contribute to cardiovascular risk stratification.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Alleles -
- Case-Control Studies -
- Coronary Angiography -
- Coronary Disease - genetics
- Gene Frequency - genetics
- Genotype - genetics
- Humans - genetics
- Interleukin-6 - blood
- Male - blood
- Middle Aged - blood
- Myocardial Infarction - genetics
- Polymorphism, Genetic - genetics
- Promoter Regions (Genetics) - genetics
- Risk Factors - genetics
- Find related publications in this database (Keywords)
- genetics
- coronary artery disease
- inflammation
- interleukin-6
- risk factors