Medizinische Universität Graz - Research portal
Selected Publication:
Speicher, MR; Jauch, A; Parr, A; Becher, R.
Delineation of translocation t(15; 17) in acute promyelocytic leukemia by chromosomal in situ suppression hybridization.
Leuk Res. 1993; 17(4):359-364
Doi: 10.1016/0145-2126(93)90024-F
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- Leading authors Med Uni Graz
- Speicher Michael
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- Abstract:
- In this study we demonstrate the feasibility of chromosomal in situ suppression (CISS) hybridization to detect the translocation t(15; 17) in metaphase spreads of patients with acute promyelocytic leukemia. Using DNA libraries from sorted human chromosomes 15 and 17 the translocation t(15; 17) can be unequivocally identified even if the spread and the morphology of the chromosomes are poor. The sensitivity of CISS hybridization is compared with the sensitivity of conventional G-banded karyotypes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Chromosome Banding -
- Chromosomes, Human, Pair 15 - physiology
- Chromosomes, Human, Pair 17 - physiology
- DNA, Neoplasm - genetics
- Female -
- Gene Library -
- Humans -
- In Situ Hybridization - methods
- Karyotyping -
- Leukemia, Promyelocytic, Acute - genetics
- Male -
- Metaphase - physiology
- Middle Aged -
- Sensitivity and Specificity -
- Translocation, Genetic -
- Find related publications in this database (Keywords)
- TRANSLOCATION T(15-17)
- ACUTE PROMYELOCYTIC LEUKEMIA
- FLUORESCENCE INSITU HYBRIDIZATION
- CHROMOSOMAL INSITU SUPPRESSION HYBRIDIZATION