Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Taniwaki, M; Speicher, MR; Lengauer, C; Jauch, A; Popp, S; Cremer, T.
Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization.
Cancer Genet Cytogenet. 1993; 70(2):99-102
Doi: 10.1016/0165-4608(93)90175-L
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Speicher Michael
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- Abstract:
- A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY, +der(1)t(1;21)(p11;?), -16,der(21)t(16;21) (p11.1;q22).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Chromosome Aberrations -
- Chromosome Banding -
- Chromosomes, Artificial, Yeast -
- Chromosomes, Human, Pair 1 -
- Chromosomes, Human, Pair 16 -
- Chromosomes, Human, Pair 21 -
- DNA Probes -
- Gene Library -
- Genetic Markers -
- Humans -
- In Situ Hybridization, Fluorescence -
- Karyotyping -
- Leukemia, Nonlymphocytic, Acute - genetics
- Male - genetics
- Monosomy - genetics
- Translocation, Genetic - genetics