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Illig, R; Exner, GU; Kollmann, F; Kellerer, K; Borkenstein, M; Lunglmayr, L; Kuber, W; Prader, A.
Treatment of cryptorchidism by intranasal synthetic luteinising-hormone releasing hormone. Results of a collaborative double-blind study.
Lancet. 1977; 2(8037): 518-520.
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Co-authors Med Uni Graz: Borkenstein Helmuth Martin
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Abstract:: The effect of intranasal luteinising-hormone releasing hormone (L.H.R.H.) in 84 boys with unilateral or bilateral cryptorchidism was evaluated in a double-blind controlled trial. Boys with retractile testes were not studied. L.H.R.H. caused no side-effects; plasma antibodies to L.H.R.H. were never demonstrated. Four weeks' therapy with intranasal L.H.R.H. administered in six doses daily (1.2 mg/day) led to complete descent in 38% of a total of 61 testes, an improved position in 28%, and no response in 19%; 15% of testes were never palpated. After placebo the position of 25% of testes was improved; there was no response in 75% of a total of 51 testes. The success-rate seemed to be independent of age, but was related to the initial testicular position, with complete descent in only 11% of testes not previously palpated compared with 48% of testes found in the inguinal region.
Find related publications in this database (using NLM MeSH Indexing): Administration, Intranasal -; Child -; Child, Preschool -; Cryptorchidism - drug therapy; Double-Blind Method - drug therapy; Gonadotropin-Releasing Hormone - administration and dosage; Humans - administration and dosage; Infant - administration and dosage; Male - administration and dosage; Placebos - administration and dosage; Testis - pathology