Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schiffrin, EJ; Trop, M; Schroeder, S; Carter, EA.
Platelet-activating factor induces intestinal necrosis, but not septic shock, in germ-free and specific-pathogen-free rodents.
Burns. 1991; 17(4): 276-278.
Doi: 10.1016/0305-4179(91)90038-I
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- Trop Marija
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- Abstract:
- Platelet-activating factor (PAF) was injected into conventional mice, endotoxin-resistant mice (C3H/HEJ), conventional rats, germ-free rats and specific-pathogen-free (SPF) mice. The PAF resulted in significant necrosis and damage to the small intestines of all the animals tested. In general, the frequency and severity of the lesions were similar in all groups. All the conventional rats and mice, as well as the endotoxin-resistant HEJ mice, were dead 18 h after the injection of the PAF, while all the germ-free rats and the SPF mice survived. These data demonstrate that development of massive intestinal lesions, in the absence of aerobic bacteria, is not sufficient to cause the death of the host from septic shock and endotoxaemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Female -
- Germ-Free Life -
- Intestine, Small - drug effects
- Lipopolysaccharides - drug effects
- Mice - drug effects
- Mice, Inbred C3H - drug effects
- Necrosis - drug effects
- Platelet Activating Factor - toxicity
- Rats - toxicity
- Salmonella typhi - toxicity
- Shock, Septic - etiology
- Specific Pathogen-Free Organisms - etiology