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Schmauss, M; Kapfhammer, HP; Meyr, P; Hoff, P.
Combined MAO-inhibitor and tri- (tetra) cyclic antidepressant treatment in therapy resistant depression.
Prog Neuropsychopharmacol Biol Psychiatry. 1988; 12(4): 523-532. Doi: 10.1016/0278-5846(88)90111-X
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Co-authors Med Uni Graz: Kapfhammer Hans-Peter
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Abstract:: 1. One aspect of using MAO-inhibitors - combining them with tricyclic antidepressants in the treatment of therapy resistant depression - has always been controversely discussed in regard to its unusual toxicity and efficacy. 2. To obtain detailled information about safety and efficacy of such a combined treatment, the charts of 94 inpatients treated with a tranylcypromine - tri- (tetra) cyclic antidepressant combination were reviewed. 3. Within a mean treatment period of 21.9 days, 68% of the patients demonstrated a very good or good improvement to combined treatment, the most effective combination being tranylcypromine + amitriptyline. 4. The incidence of side effects among the patients on the combined regimen was slightly, but not significantly lower as compared to the patients on single tri- (tetra) cyclic antidepressant treatment. 5. Our retrospective study supports the general safety and efficacy of combined MAOI-TCA treatment and suggests that combined treatment, if properly administered, leads to neither serious complications nor an inordinate number of side effects.
Find related publications in this database (using NLM MeSH Indexing): Antidepressive Agents - adverse effects; Blood Pressure - drug effects; Body Weight - drug effects; Depressive Disorder - drug therapy; Dose-Response Relationship, Drug - drug therapy; Drug Administration Schedule - drug therapy; Drug Therapy, Combination - drug therapy; Heart Rate - drug effects; Humans - drug effects; Tranylcypromine - adverse effects; Trifluoperazine - adverse effects