Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, P.
Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tract.
Am J Physiol Gastrointest Liver Physiol. 2007; 292(3): G699-G705.
Doi: 10.1152/ajpgi.00517.2006
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- Luminal acidity is a physiological challenge in the foregut, and acidosis can occur throughout the gastrointestinal tract as a result of inflammation or ischemia. These conditions are surveyed by an elaborate network of acid-governed mechanisms to maintain homeostasis. Deviations from physiological values of extracellular pH are monitored by multiple acid sensors expressed by epithelial cells and sensory neurons. Acid-sensing ion channels are activated by moderate acidification, whereas transient receptor potential ion channels of the vanilloid subtype are gated by severe acidosis. Some ionotropic purinoceptor ion channels and two-pore domain background K(+) channels are also sensitive to alterations of extracellular pH.
- Find related publications in this database (using NLM MeSH Indexing)
- Acidosis - metabolism
- Acids - metabolism
- Animals - metabolism
- Chemoreceptors - physiology
- Gastrointestinal Tract - physiology
- Humans - physiology
- Membrane Proteins - physiology
- Nerve Tissue Proteins - physiology
- Sodium Channels - physiology
- TRPV Cation Channels - physiology
- Find related publications in this database (Keywords)
- acidosis
- acid-induced motor programs
- acid-sensing ion channels
- gastric acid
- hyperalgesia
- inflammation
- ionotropic purinoceptor ion channels
- ischemia
- mucosal protection
- pain
- transient receptor potential ion channels of the vanilloid subtype
- two-pore domain potassium channels