Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hauer, AC.
Probiotics and allergy
MONATSSCHR KINDERHEILK. 2002; 150(7): 829-+.
Doi: 10.1007/s00112-002-0504-1
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Hauer Almuthe
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- Abstract:
- For years there has been an increasing interest in the potential use of probiotics in allergy prevention and treatment, as they seem to influence the pathomechanisms leading to allergic disease at various levels: Probiotics stimulate the physiological intestinal flora necessary for maturation of the intestinal immune system and they help stabilise the intestinal barrier. They also induce specific and unspecific defense mechanisms in the gut, i.e. antigen specific humoral immune responses, and seem to counteract the dominance of the atopy-associated Th2-type cytokine profile. Therefore they could be of particular importance for newborns and infants in our part of the world, whose intestinal flora - due to environmental factors - has changed in composition and maturation, thus affecting the development of intestinal immune functions. Some smaller controlled studies have shown a clear clinical benefit of probiotics for infants with atopic dermatitis - both in terms of prevention and treatment. However, further experimental work is needed to explain the exact underlying mechanisms and clinical studies should demonstrate the various clinical effects of probiotics on a broader level, before they can be generally recommended in the context of allergy.
- Find related publications in this database (Keywords)
- probiotics
- allergy
- gut flora
- intestinal immunity
- infants