Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kornprat, P; Jarnagin, WR; Gonen, M; DeMatteo, RP; Fong, Y; Blumgart, LH; D'Angelica, M.
Outcome after hepatectomy for multiple (four or more) colorectal metastases in the era of effective chemotherapy.
Ann Surg Oncol. 2007; 14(3):1151-1160
Doi: 10.1245/s10434-006-9068-y
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- Leading authors Med Uni Graz
- Kornprat Peter
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- Abstract:
- Hepatic resection is generally accepted as the only potential for long-term survival in patients with colorectal metastases confined to the liver. Despite an unknown benefit, hepatic resection is playing an increasing role in patients with extensive disease. A retrospective review of a prospectively maintained hepatobiliary surgical database was carried out. Outcome after hepatectomy for four or more colorectal hepatic metastases was reviewed. Between 1998 and 2002, out of a total of 584 patients, 98 (17%) with four or more colorectal hepatic metastases were resected. Actuarial 5-year survival was 33% for the entire group, with seven actual 5-year survivors. There were no perioperative deaths, and the perioperative morbidity was 28%. Positive margins and extrahepatic disease resection were independently associated with poor outcome. The median disease-free survival was 12 months, with no actuarial disease-free survivors at 5 years. Recurrence pattern, response to neoadjuvant chemotherapy, time to recurrence, and resection of recurrent disease were also associated with outcome. Long-term survival can be achieved after resection of multiple colorectal metastases; however, because most patients will experience recurrence of disease, effective adjuvant therapy and close follow-up is necessary.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Chemotherapy, Adjuvant -
- Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery
- Combined Modality Therapy -
- Female -
- Follow-Up Studies -
- Hepatectomy -
- Humans -
- Liver Neoplasms - drug therapy Liver Neoplasms - secondary Liver Neoplasms - surgery
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoadjuvant Therapy -
- Neoplasm Invasiveness -
- Neoplasm Recurrence, Local -
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- liver metastases
- colorectal
- multiple
- hepatectomy