Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Madeo, F; Fröhlich, E; Ligr, M; Grey, M; Sigrist, SJ; Wolf, DH; Fröhlich, KU.
Oxygen stress: a regulator of apoptosis in yeast.
J Cell Biol. 1999; 145(4):757-767 Doi: 10.1083/jcb.145.4.757 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: Fröhlich Eleonore
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Abstract:: Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2. Cycloheximide prevents apoptotic death revealing active participation of the cell. Yeast can also be triggered into apoptosis by a mutation in CDC48 or by expression of mammalian bax. In both cases, we show oxygen radicals to accumulate in the cell, whereas radical depletion or hypoxia prevents apoptosis. These results suggest that the generation of oxygen radicals is a key event in the ancestral apoptotic pathway and offer an explanation for the mechanism of bax-induced apoptosis in the absence of any established apoptotic gene in yeast.
Find related publications in this database (using NLM MeSH Indexing): Apoptosis -; Biological Markers -; Cell Cycle Proteins - genetics; Cycloheximide - pharmacology; Fungal Proteins - genetics; Glutathione - metabolism; Hydrogen Peroxide - pharmacology; Mutagenesis - pharmacology; Oxidative Stress - pharmacology; Oxygen - pharmacology; Phenotype - pharmacology; Protein Synthesis Inhibitors - pharmacology; Proto-Oncogene Proteins - biosynthesis; Proto-Oncogene Proteins c-bcl-2 - biosynthesis; Reactive Oxygen Species - metabolism; Saccharomyces cerevisiae - cytology; bcl-2-Associated X Protein - cytology
Find related publications in this database (Keywords): apoptosis; glutathione; oxygen stress; reactive oxygen species; Saccharomyces cerevisiae