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Selected Publication:
Brunner, F; Stessel, H; Graier, WF.
The effects of intracellular Ca2+ concentration and hypoxia on basal endothelin-1 secretion by cultured porcine aortic endothelial cells.
Agents Actions Suppl. 1995; 45:269-273
Doi: 10.1007/978-3-0348-7346-8_36
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- Co-authors Med Uni Graz
- Graier Wolfgang
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- Abstract:
- When the intracellular free Ca2+ concentration ([Ca2+]i) of porcine aortic endothelial cells incubated in normoxic or hypoxic atmosphere was varied more than tenfold, basal endothelin-1 (ET-1) secretion was maximal at control conditions ([Ca2+]i = 190 nM) and reduced at lower and higher [Ca2+]i. High [Ca2+]i reduced ET-1 synthesis only in part via activation of the NO/cGMP system. Our results provide evidence that basal ET-1 secretion is regulated by [Ca2+]i, and that Ca2+ plays a similar role in hypoxic and normoxic signal transduction.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aorta - metabolism
- Calcium - metabolism
- Cell Hypoxia - physiology
- Cells, Cultured - physiology
- Cyclic GMP - metabolism
- Endothelins - metabolism
- Endothelium, Vascular - metabolism
- Intracellular Fluid - metabolism
- Radioimmunoassay - metabolism
- Swine - metabolism