Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Talwar, S; Siebenhofer, A; Williams, B; Ng, L.
Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP.
HEART. 2000; 83(3): 278-282.
Doi: 10.1136/heart.83.3.278
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- Co-Autor*innen der Med Uni Graz
- Siebenhofer-Kroitzsch Andrea
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- Abstract:
- OBJECTIVES: To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN: Prospective study. SETTING: Teaching hospital based study. PATIENTS: NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index (WMI) between 1.9-1.3; and group 5:17 patients with a history of hypertension, no history of ischaemic heart disease, and WMI < 1.2. RESULTS: Median (range) NT proBNP concentrations (in fmol/ml) for groups 1-5, respectively, were: 129.4 (53.6-159.7), 147.4 (54.3-730. 5), 137.1 (35.8-403.9), 356.7 (124.4-934.4), and 493.5 (248.9-909). Mean log NT proBNP differed among all five groups (p < 0.0001), and between groups 4 and 5 versus groups 1-3 (p < 0.0001), and group 4 versus group 5 (p = 0.02) only. CONCLUSIONS: The results suggest that the presence of hypertension with or without LVH (and normal left ventricular systolic function) does not affect NT proBNP concentrations. Moreover, there is a significant rise in NT proBNP only when LVSD develops in hypertension. Thus, NT proBNP remains a useful diagnostic aid for LVSD, even in hypertensive patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Cross-Sectional Studies -
- Female -
- Humans -
- Hypertension - blood
- Hypertrophy, Left Ventricular - blood
- Male - blood
- Middle Aged - blood
- Natriuretic Peptide, Brain - blood
- Nerve Tissue Proteins - blood
- Peptide Fragments - blood
- Prospective Studies - blood
- Regression Analysis - blood
- Ventricular Dysfunction, Left - blood
- Find related publications in this database (Keywords)
- hypertension
- brain natriuretic peptide
- left ventricular hypertrophy
- left ventricular systolic dysfunction
- chemiluminescence