Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
O'Neill, TW; Silman, AJ; Naves Diaz, M; Cooper, C; Kanis, J; Felsenberg, D.
Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women. European Vertebral Osteoporosis Study Group.
Osteoporos Int. 1997; 7(1): 72-78.
Doi: 10.1007/BF01623464
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- Study Group Mitglieder der Med Uni Graz:
- Weber Kurt
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- Abstract:
- The aim of this study was to determine whether variation in the level of selected hormonal and reproductive variables might explain variation in the occurrence of vertebral deformity across Europe. A population-based cross-sectional survey method was used. A total of 7530 women aged 50-79 years and over were recruited from 30 European centres. Subjects were invited to attend for an interviewer-administered questionnaire and lateral spinal radiographs which were taken according to a standard protocol. After adjusting for age, centre, body mass index and smoking, those in the highest quintile of menarche (age > or = 16 years) had an increased risk of vertebral deformity (odds ratio [OR] = 1.48; 95% confidence interval [CI] 1.16, 1.88). Increased menopausal age (> 52.5 years) was associated with a reduced risk of deformity (OR = 0.78; 95% CI 0.60, 1.00), while use of the oral contraceptive pill was also protective (OR = 0.76; 95% CI 0.58, 0.99). There was a smaller protective effect associated with one or more years use of hormone replacement therapy, though the confidence limits clearly embraced unity. There was no apparent effect of parity or breast-feeding on the risk of deformity. We conclude that oestrogen status is an important determinant of vertebral deformity. Ever use of the oral contraceptive pill was associated with a 25% reduction in risk of deformity though the effect may be a result of the higher-dosage oestrogen pills used in the past. Parity and breast-feeding do not appear to be important and would appear to have little potential for identification of women at high risk of vertebral deformity.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Contraceptives, Oral, Hormonal -
- Estrogen Replacement Therapy -
- Female -
- Humans -
- Joint Deformities, Acquired - etiology
- Male - etiology
- Menarche - etiology
- Menopause - etiology
- Middle Aged - etiology
- Osteoporosis, Postmenopausal - etiology
- Reproductive History - etiology
- Risk Factors - etiology
- Spinal Diseases - etiology
- Find related publications in this database (Keywords)
- menarche
- menopause
- oral contraceptive pill
- parity
- vertebral osteoporosis