Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gilsbach, JM; Reulen, HJ; Ljunggren, B; Brandt, L; von Holst, H; Mokry, M; von Essen, C; Conzen, MA.
Early aneurysm surgery and preventive therapy with intravenously administered nimodipine: a multicenter, double-blind, dose-comparison study.
Neurosurgery. 1990; 26(3): 458-464.
Doi: 10.1227/00006123-199003000-00013
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- Co-Autor*innen der Med Uni Graz
- Mokry Michael
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- Abstract:
- A European, multicenter, prospective, randomized, double-blind, dose-comparison study on preventive therapy with intravenously administered nimodipine was performed to evaluate the efficacy and tolerability of two different doses: 2 and 3 mg/h. Two hundred four patients fulfilled the criteria for enrollment in the study: surgery within 72 hours after the last subarachnoid hemorrhage, and age between 16 and 72 years. All patients who had Hunt and Hess grades of I to III were operated upon; patients who had poor Hunt and Hess grades (IV-V) were operated on according to the surgeon's choice. This treatment regimen was associated with a low incidence of delayed neurological dysfunction with no significant difference between the two dosage groups: three patients (1.5%) remained severely disabled and two (1%) moderately disabled due to vasospasm with or without additional complications. Among the patients with Hunt and Hess grades of IV or V, the long-term outcome was favorable (good-fair) for 40% and unfavorable for 60%. Among the patients with grades of I to III, the long-term outcome was favorable for 89% and unfavorable for 11%.
- Find related publications in this database (using NLM MeSH Indexing)
- Dose-Response Relationship, Drug -
- Double-Blind Method -
- Female -
- Humans -
- Injections, Intravenous -
- Intracranial Aneurysm - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Multicenter Studies - drug therapy
- Nimodipine - administration and dosage