Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schauenstein, K; Rinner, I; Felsner, P; Liebmann, P; Haas, HS; Wölfler, A; Stevenson, R; Westermann, J; Cohen, RL; Chambers, DA.
The dialogue between the brain and immune system involves not only the HPA-axis.
Z Rheumatol. 2000; 59 Suppl 2(6): II/49-II/53.
Doi: 10.1007/s003930070018
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- Führende Autor*innen der Med Uni Graz
- Schauenstein Konrad
- Co-Autor*innen der Med Uni Graz
- Haas Helga Susanne
- Liebmann-Holzmann Peter
- Wölfler Albert
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- Abstract:
- Starting out from our previous observations that defects in the immune system-brain feedback predispose to pathogenic immune responses, our interest focuses at the roles of adrenergic/cholinergic neurotransmitters in brain-immune interactions. We have shown in rodent models that 1) both catecholamines and acetylcholine are potent modulators of peripheral immune functions, 2) cholinergic signals are involved in the afferent signalling of the immune system, and 3) lymphocytes not only express functional adrenergic and cholinergic receptors, but synthesize and release neurotransmitters, such as acetylcholine, in quantitative dependence of differentiation and activation. Studies are presently being initiated to investigate the role(s) of these non-neuronal neurotransmitters within immune tissues, and to explore the relevance of excitatory amino acids as important central neurotransmitters in the brain-immune system dialogue.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcholine - immunology
- Animals - immunology
- Autoimmune Diseases - immunology
- Autonomic Nervous System - physiopathology
- Brain - physiopathology
- Catecholamines - physiology
- Feedback - physiology
- Humans - physiology
- Hypothalamo-Hypophyseal System - physiopathology
- Lymphocyte Activation - immunology
- Mice - immunology
- Pituitary-Adrenal System - physiopathology
- Rats - physiopathology
- Find related publications in this database (Keywords)
- psychoneuroimmunology
- autonomic nervous system
- catecholamines
- acetylcholine
- immunoregu