Medizinische Universität Graz - Research portal
Selected Publication:
Gössnitzer, E; Malli, R; Schuster, S; Favre, B; Ryder, NS.
Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. Part I: synthesis and antifungal activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines.
Arch Pharm (Weinheim). 2002; 335(11-12): 535-546.
Doi: 10.1002/ardp.200290007
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- Co-authors Med Uni Graz
- Malli Roland
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- Abstract:
- A series of N-alkyl-N'-(phenethyl- and cyclohexenylethyl) guanidines and N(2)- and N(2), 4-substituted imidazolin-2-amine hydrochlorides with triazasterol-related structures was designed and synthesized as stable analogues to mimic high energy intermediates of ergosterol biosynthesis. The in vitro antifungal susceptibility tests with a standard panel of pathogenic fungi revealed moderate to strong antimycotic effects of the sixteen prepared compounds, in some cases comparable with the activity observed for itraconazole.
- Find related publications in this database (using NLM MeSH Indexing)
- Antifungal Agents - chemical synthesis
- Ergosterol - biosynthesis
- Fungi - drug effects
- Guanidines - chemical synthesis
- Imidazoles - chemical synthesis
- Magnetic Resonance Spectroscopy - chemical synthesis
- Microbial Sensitivity Tests - chemical synthesis
- Structure-Activity Relationship - chemical synthesis