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Selected Publication:
Grasser, B; Iberer, F; Schreier, G; Allmayer, A; Schaffellner, S; Prenner, G; Wasler, A; Petutschnigg, B; Müller, H; Tscheliessnigg, K.
Intramyocardial electrograms for non-invasive rejection monitoring: initial experience with an infection-specific parameter.
Transpl Int. 1998; 11 Suppl 1(11 Pt 2): S508-S511.
Doi: 10.1111/j.1432-2277.1998.tb01192.x
PubMed
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- Co-authors Med Uni Graz
- Iberer Florian
- Müller Helmut
- Prenner Günther
- Schaffellner Silvia
- Tscheliessnigg Karlheinz
- Wasler Andrae
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- Abstract:
- Non-invasive rejection monitoring based on the analysis of paced intramyocardial electrograms enables repeated or even daily graft surveillance. The rejection-sensitive parameter is calculated from the maximum slope of the descending part of the t wave. Biopsy-proven rejection grade 2 or higher (ISHLT classification) can safely be detected. Nevertheless, infection influences the rejection-sensitive parameter in the same manner as does rejection (99% negative predictive value for rejection grade 2 or higher, 17% positive predictive value). We defined the infection-specific parameter as the time on the O line between the pacemaker stimulus and the crossover with the maximum slope of the descending part of the t wave. Patients were classified prospectively according to infection status: patients without infection and those with clinically apparent infection. Patients with clinically apparent infections had a significantly longer infection-specific parameter. A simultaneous decrease of the rejection-sensitive parameter and an increase in the infection-specific parameter was observed during clinical infection: a decrease in the rejection-sensitive parameter and no changes in the infection-specific parameter were observed during rejection. This preliminary analysis revealed that discrimination of rejection and infection might be possible by the analysis of intramyocardial electrograms.
- Find related publications in this database (using NLM MeSH Indexing)
- Diagnosis, Differential -
- Electrocardiography - methods
- Graft Rejection - diagnosis
- Heart Transplantation - physiology
- Humans - physiology
- Infection - diagnosis
- Monitoring, Physiologic - diagnosis
- Predictive Value of Tests - diagnosis
- Prospective Studies - diagnosis