Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Vukicevic, S; Stavljenic, A; Boll, T; Cervar, M; Degenhardt, C; Mihaljevic, T; Krempien, B.
The influence of early parathyroidectomy on aluminum-induced rickets in growing uremic rats.
Bone Miner. 1989; 6(2): 125-139.
Doi: 10.1016/0169-6009(89)90045-7
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- Cervar-Zivkovic Mila
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- Abstract:
- Rats were subjected to a two-stage 5/6 nephrectomy and treated with aluminum for 2 and 4 weeks with a cumulative dose of 4.2 and 8.4 mg of aluminum, respectively. Other animals were parathyroidectomized and loaded with 8.4 mg of aluminum for 4 weeks. Histomorphometry and electron microscopy (tibiae), aluminum tissue (bone, kidney, liver) determination, serum (Ca, Mg, Zn, P, urea, creatinine, alkaline phosphatase, 1,25(OH)2D3, PTH) and urine (creatinine, A1) revealed that: (a) a dose of 8.4 mg aluminum was sufficient to induce rickets within 4 weeks of treatment and was associated with decreased serum calcitriol values and high aluminum accumulation within organs (electron-dense material was found in osteoblasts only); (b) previous parathyroidectomy prevented the occurrence of any aluminum-induced alteration of bone. It was associated with higher calcitriol and phosphorus values than in corresponding non-parathyroidectomized rats and significantly reduced aluminum accumulation within organs. The results was influenced neither by a drop in serum calcium values nor by different degrees of renal failure. We suggest that aluminum-induced rickets in growing uremic rats is prevented or delayed when previous parathyroidectomy has been performed.
- Find related publications in this database (using NLM MeSH Indexing)
- Aluminum - adverse effects
- Animals - adverse effects
- Bone and Bones - metabolism
- Calcitriol - blood
- Calcium - blood
- Creatine - blood
- Kidney - analysis
- Liver - analysis
- Male - analysis
- Microscopy, Electron - analysis
- Parathyroid Glands - surgery
- Phosphorus - blood
- Rats - blood
- Rats, Inbred Strains - blood
- Rickets - chemically induced
- Urea - blood
- Uremia - metabolism