Medizinische Universität Graz - Research portal
Selected Publication:
Dörner, T; Brezinschek, HP; Foster, SJ; Brezinschek, RI; Farner, NL; Lipsky, PE.
Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5- and IgM+/CD5+ B cells.
Eur J Immunol. 1998; 28(2):657-668
Doi: 10.1002/(SICI)1521-4141(199802)28:02<657::AID-IMMU657>3.0.CO;2-Z
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- Co-authors Med Uni Graz
- Brezinsek Hans-Peter
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- Abstract:
- Somatic hypermutation and subsequent selection play a significant role in shaping the peripheral B cell repertoire. This repertoire is composed of CD5+ (5%) and CD5- B cells (95%) which are known to traffic through different lymphoid compartments. Previous studies have shown that V(H) gene usage by CD5+ and CD5- B cells is similar, although mutations are more frequent in the latter. However, the effect of mutation and subsequent selection on the expressed V(H) repertoire of CD5+ and CD5- B cells has not been delineated in detail. This study, therefore, analyzed the mutational pattern of individual IgM+/CD5+ and IgM+/CD5- B cells. In both populations, mutations can occur without heavy chain isotype switching. Despite the differences in mutational frequency, the patterns of mutation and subsequent selection were comparable in CD5+ and CD5- B cells. These results imply that although mutations are more frequent in CD5- B cells, the overall mechanisms governing somatic hypermutation and subsequent positive and negative selection are similar in CD5+ and CD5- B cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenine -
- Adult -
- Antigens, CD5 - genetics
- B-Lymphocyte Subsets - immunology
- Codon - genetics
- Cytosine - genetics
- DNA Mutational Analysis - statistics and numerical data
- Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics
- Guanine - genetics
- Humans - genetics
- Immunoglobulin Heavy Chains - biosynthesis
- Immunoglobulin Joining Region - biosynthesis
- Immunoglobulin M - genetics
- Immunoglobulin Variable Region - biosynthesis
- Male - biosynthesis
- Middle Aged - biosynthesis
- Molecular Sequence Data - biosynthesis
- Mutation - biosynthesis
- Purine Nucleotides - genetics
- Serine - genetics
- Statistics, Nonparametric - genetics
- Find related publications in this database (Keywords)
- somatic hypermutation
- antibody
- B lymphocyte
- generation of diversity