Medizinische Universität Graz - Research portal
Selected Publication:
Herold, M; Brezinschek, HP; Gruschwitz, M; Dietrich, H; Wick, G.
Investigation of ACTH responses of chickens with autoimmune disease.
Gen Comp Endocrinol. 1992; 88(2):188-198
Doi: 10.1016/0016-6480(92)90250-N
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- Co-authors Med Uni Graz
- Brezinsek Hans-Peter
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- Abstract:
- An altered immunoendocrine feedback regulation within the hypothalamo-pituitary-adrenal axis may modulate the pathogenesis of an avian autoimmune disease. To date studies have been hampered by a lack of reliable, specific, and sensitive methods for determining adrenocorticotropic hormone (ACTH) in chickens. The present study describes the determination of ACTH in plasma of chickens with a commercial radioimmunoassay, the antibody of which binds to the midregion of human ACTH 1-39. The chickens, kept on a 12-hr day and 12-hr night shift with artificial light, showed changes in plasma ACTH concentrations during the light phase with maximum values 8 hr after the light was turned on. ACTH was not measurable after treatment with dexamethasone. Intravenous administration of supernatants from concanavalin A-stimulated spleen cells increased basal plasma ACTH concentrations more than 20-fold within 1 hr. This increase in plasma ACTH was higher and longer lasting in UCD 200 chickens, an animal model for scleroderma, compared with outbred and inbred normal White Leghorn chickens.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenocorticotropic Hormone - blood
- Animals - blood
- Autoimmune Diseases - blood
- Cell Extracts - blood
- Chickens - immunology
- Corticosterone - blood
- Dexamethasone - pharmacology
- Disease Models, Animal - pharmacology
- Feedback - pharmacology
- Hypothalamo-Hypophyseal System - drug effects
- Immunoradiometric Assay - drug effects
- Interleukin-1 - pharmacology
- Light - pharmacology
- Pituitary-Adrenal System - drug effects
- Poultry Diseases - immunology
- Radioimmunoassay - immunology
- Scleroderma, Systemic - blood
- Spleen - physiology
- Time Factors - physiology