Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmidt, HH; Renner, H; Linkesch, W.
Intrapleural instillation of rituximab for the treatment of malignant pleural effusions in NHL.
Haematologica. 2004; 89(11): ECR39-ECR39.
(- Case Report)
[OPEN ACCESS]
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- Führende Autor*innen der Med Uni Graz
- Schmidt Helmut
- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Renner Heiko
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- Abstract:
- A patient with CD20(+) leukaemic lymphoplasmacytic Non-Hodgkin's lymphoma (NHL) presented with bilateral malignant pleural effusions. Systemic chemotherapy, repeated percutaneous drainage and bilateral continous chest tube drainage were unable to control the effusions. Rituximab was instilled in a dose-escalating manner via the chest tubes into both pleural spaces, within two weeks the effusions resolved, and the patient has stayed free of symptoms for eight months ongoing. Rituximab may be a promising novel treatment option for malignant effusions in CD20(+) NHL.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal - therapeutic use
- Antigens, CD20 - immunology
- Antineoplastic Agents - therapeutic use
- Humans -
- Instillation, Drug -
- Lymphoma, Non-Hodgkin - complications Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - immunology
- Male -
- Middle Aged -
- Pleura - drug effects
- Pleural Effusion, Malignant - drug therapy Pleural Effusion, Malignant - etiology Pleural Effusion, Malignant - immunology