Medizinische Universität Graz - Research portal
Selected Publication:
Sigl, E; Behmel, A; Henn, T; Wirnsberger, G; Weinhausl, A; Kaserer, K; Niederle, B; Pfragner, R.
Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.
Int J Oncol. 1999; 15(1):41-51
Doi: 10.3892/ijo.15.1.41
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Pfragner Roswitha
- Co-authors Med Uni Graz
- Wirnsberger Gerhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A malignant insulinoma (LOHG-I), a carcinoid of the lung (LOHG-L), a parathyroid adenoma (LOHG-NSA), and a fibroma (LOHG-F) were obtained from a patient with multiple endocrine neoplasia type 1 (MEN1). Long-term cultures were established. Essential neurobiological properties of the cell lines were proven immunocytochemically and by electron microscopy. Molecular analysis of the germline DNA showed a 4 bp deletion in exon 3 of the MEN1 gene. Cytogenetic and CGH analyses of the tumors/tumor cell lines revealed diploidy and balanced and unbalanced structural aberrations different for each tumor. Chromosomes 6q21, 11q and 17q were most frequently involved in clonal structural aberrations.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - genetics
- Adrenal Gland Neoplasms - pathology
- Adult - pathology
- Aneuploidy - pathology
- Carcinoid Tumor - genetics
- Chromosome Aberrations - genetics
- Chromosomes, Human, Pair 11 - genetics
- DNA Mutational Analysis - genetics
- DNA, Neoplasm - genetics
- Esophageal Neoplasms - pathology
- Fibroma - genetics
- Genes, Tumor Suppressor - genetics
- Humans - genetics
- Insulinoma - genetics
- Leiomyoma - pathology
- Lung Neoplasms - genetics
- Male - genetics
- Multiple Endocrine Neoplasia Type 1 - genetics
- Neoplasm Proteins - deficiency
- Nucleic Acid Hybridization - deficiency
- Pancreatic Neoplasms - genetics
- Parathyroid Neoplasms - genetics
- Pheochromocytoma - pathology
- Proto-Oncogene Proteins - pathology
- Sequence Deletion - pathology
- Skin Neoplasms - genetics
- Tumor Cells, Cultured - genetics
- Find related publications in this database (Keywords)
- Multiple Endocrine Neoplasia Type 1
- Insulinoma
- Bronchial Carcinoid
- Parathyroid Adenoma
- Fibroma
- Cell Culture
- Cytogenetics
- Comparative Genomic Hybridization
- Mutation Analysis