Medizinische Universität Graz - Research portal
Selected Publication:
Lipitz, S; Ryan, G; Murphy, MF; Robson, SC; Haeusler, MC; Metcalfe, P; Kelsey, H; Rodeck, CH.
Neonatal alloimmune thrombocytopenia due to anti-P1A1 (anti-HPA-1a): importance of paternal and fetal platelet typing for assessment of fetal risk.
Prenat Diagn. 1992; 12(11):955-958
Doi: 10.1002/pd.1970121116
(- Case Report)
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- Co-authors Med Uni Graz
- Haeusler Martin
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- Abstract:
- Neonatal alloimmune thrombocytopenia (NAIT), which usually involves sensitization to P1A1 (HPA-1a), may have devastating complications for the fetus. These may be prevented by antenatal treatment of severe cases with either maternally administered high-dose gamma-globulin and/or repeated intrauterine platelet transfusions. Determination of the paternal platelet phenotype is useful for counseling parents who have had one or more affected pregnancies. This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, Human Platelet - analysis
- Autoimmune Diseases - diagnosis Autoimmune Diseases - therapy
- Blood Component Transfusion -
- Blood Platelets - immunology
- Female -
- Fetal Blood - cytology
- Fetal Diseases - diagnosis Fetal Diseases - therapy
- Humans -
- Immunophenotyping -
- Infant, Newborn -
- Male -
- Pregnancy -
- Pregnancy Trimester, Second -
- Prenatal Diagnosis -
- Risk -
- Thrombocytopenia - diagnosis Thrombocytopenia - therapy
- Find related publications in this database (Keywords)
- FETAL NEONATAL ALLOIMMUNE THROMBOCYTOPENIA
- FETAL BLOOD SAMPLING
- PATERNAL PLATELET
- PHENOTYPE