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Uhlig, T; Eber, E; Devadason, SG; Pemberton, P; Badawi, N; LeSouef, PN; Wildhaber, JH.
Aerosol delivery to spontaneously breathing neonates: Spacer or nebulizer?
PEDIATR ASTHMA ALLERG IMMUN. 1997; 11(2): 111-117. Doi: 10.1089/pai.1997.11.111
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Co-authors Med Uni Graz: Eber Ernst
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Abstract:: Aims: We chose to compare aerosol delivery from a nebulizer and a pressurized metered-dose inhaler (pMDI) through a small-volume spacer in spontaneously breathing newborn infants. Methods: Twenty-four neonates (weight 1800g-5260g) inhaled salbutamol solution from a Pari-Baby nebulizer and salbutamol puffs from a pMDI through a Nebuchamber in random order, A filter was placed between the inhalation systems and the airway opening. Results: The amount of drug deposited on the filter (expressed as percentage of the total nebulized or actuated doses) was higher with the pMDI plus the Nebuchamber than with the Pari-Baby (39.3 +/- 2.0% vs, 21.6 +/- 2.1%), Body weight and crying did not influence drug delivery. Conclusions: Aerosol delivery to spontaneously breathing neonates with a pMDI through a small-volume spacer provides a viable alternative to nebulizer therapy, (Pediatr Asthma Allergy Immunol 1997;11[2]111-117.)