Medizinische Universität Graz - Research portal
Selected Publication:
Eber, E; Zach, M; Engele, H; Haas, J; Pürstner, P; Mutz, I; Litscher, H.
Mucoviscidosis screening with immunoreactive trypsin. Initial experiences in Austria
Monatsschr Kinderheilkd. 1992; 140(7):411-415
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Eber Ernst
- Co-authors Med Uni Graz
- Haas Josef
- Pürstner Peter
- Zach Maximilian
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- Abstract:
- Up to now, 16.338 IRT-measurements have been carried out on dried blood spot specimens; 15.505 of them were taken in the first week of life. Related to a provisionally chosen cut-off point of 750 ng/ml, 134 newborns (= 0.86%) showed an elevated IRT-value and subsequently were recalled between the fourth and sixth week of life for a second IRT-determination. Twenty-five out of 116 reinvestigated children again showed an elevated value, as based on likewise provisional, age-dependent reference values. Four of these children subsequently were identified as CF patients by sweat testing. So far, we did not encounter any false-negative IRT values. We also commenced to establish a profile of reference values for the first twelve weeks of life; as yet, there are not enough data for definitely defining these limits of normality. In conclusion, IRT-screening appears to be a reliable method for identifying CF patients in the newborn period. Our preliminary results indicate an incidence of CF of 1 to 3880 in the southeast of Austria.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria - epidemiology
- Cross-Sectional Studies - epidemiology
- Cystic Fibrosis - blood
- Humans - blood
- Incidence - blood
- Infant - blood
- Infant, Newborn - blood
- Neonatal Screening - methods
- Radioimmunoassay - methods
- Reference Values - methods
- Trypsin - blood
- Find related publications in this database (Keywords)
- IMMUNOREACTIVE TRYPSIN (IRT)
- CYSTIC FIBROSIS (CF)
- NEWBORN SCREENING