Medizinische Universität Graz - Research portal
Selected Publication:
Uhlig, T; Cooper, D; Eber, E; McMenamin, C; Wildhaber, JH; Sly, PD.
Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma.
Clin Exp Allergy. 1998; 28(6):758-764
Doi: 10.1046/j.1365-2222.1998.00309.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Eber Ernst
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- Abstract:
- BACKGROUND: Short-term treatment with leflunomide is effective in suppressing antigen-specific antibody production and allergen-induced bronchoconstriction after sensitization. This agent may thus have a role in future primary prevention strategies in allergic disease. OBJECTIVE: The current study aimed to determine whether long-term oral treatment with leflunomide prevents allergic sensitization permanently. METHODS: After sensitization with ovalbumin, six groups of rats (n = 31) were treated daily with leflunomide or diluent for up to 30 days. Ovalbumin-specific IgE and IgG were determined weekly for at least 2 weeks after cessation of treatment. T lymphocytes from another 21 animals were stimulated ex vivo with ovalbumin or concanavalin A. RESULTS: Ovalbumin-specific IgE and IgG were lower during treatment with leflunomide compared with controls (P < 0.002) but increased after the cessation of treatment. Antigen-specific T-cell proliferation was decreased in cells obtained from leflunomide treated animals (P < 0.05), but not when stimulated with concanavalin A. Eosinophil (P < 0.0001) and neutrophil (P < 0.02) numbers in bronchoalveolar lavage 24 h after allergen challenge were lower in the leflunomide treated animals. CONCLUSIONS: Leflunomide prevents antigen-specific immunoglobulin production after sensitization during treatment, inhibits allergen-induced airway inflammation and diminishes antigen-specific T lymphocyte proliferation.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Inhalation -
- Administration, Oral -
- Age Factors -
- Animals -
- Anti-Inflammatory Agents - administration and dosage
- Antibody Specificity - drug effects
- Asthma - blood
- Bronchoalveolar Lavage Fluid - cytology
- Cell Division - drug effects
- Disease Models, Animal - drug effects
- Immunoglobulin E - blood
- Immunoglobulin G - blood
- Isoxazoles - administration and dosage
- Male - administration and dosage
- Ovalbumin - immunology
- Rats - immunology
- Rats, Inbred BN - immunology
- T-Lymphocytes - drug effects
- Time Factors - drug effects
- Find related publications in this database (Keywords)
- leflunomide
- acute-phase reaction
- bronchoalveolar lavage fluid
- immunoglobulins
- allergic sensitization
- immunomodulators
- isoxazoles