Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Helmberg, W.
Storage and utilization of HLA genomic data--new approaches to HLA typing.
Rev Immunogenet. 2000; 2(4): 468-476.
PubMed

Leading authors Med Uni Graz: Helmberg Wolfgang
Altmetrics:
Dimensions Citations:
Plum Analytics:
Abstract:: Currently available DNA-based HLA typing assays can provide detailed information about sequence motifs of a tested sample. It is still a common practice, however, for information acquired by high-resolution sequence specific oligonucleotide probe (SSOP) typing or sequence specific priming (SSP) to be presented in a low-resolution serological format. Unfortunately, this representation can lead to significant loss of useful data in many cases. An alternative to assigning allele equivalents to suchDNA typing results is simply to store the observed typing pattern and utilize the information with the help of Virtual DNA Analysis (VDA). Interpretation of the stored typing patterns can then be updated based on newly defined alleles, assuming the sequence motifs detected by the typing reagents are known. Rather than updating reagent specificities in individual laboratories, such updates should be performed in a central, publicly available sequence database. By referring to this database, HLA genomic data can then be stored and transferred between laboratories without loss of information. The 13th International Histocompatibility Workshop offers an ideal opportunity to begin building this common database for the entire human MHC.
Find related publications in this database (using NLM MeSH Indexing): Base Sequence -; DNA - genetics; Databases, Nucleic Acid - genetics; Genome, Human - genetics; HLA Antigens - genetics; HLA-DR Antigens - genetics; Histocompatibility Testing - statistics and numerical data; Humans - statistics and numerical data; Immunogenetics - statistics and numerical data; Information Storage and Retrieval - statistics and numerical data; Molecular Probe Techniques - statistics and numerical data; Molecular Sequence Data - statistics and numerical data; Sequence Homology, Nucleic Acid - statistics and numerical data; Software - statistics and numerical data; User-Computer Interface - statistics and numerical data