Medizinische Universität Graz - Research portal
Selected Publication:
Knobler, RM; Graninger, W; Graninger, W; Lindmaier, A; Trautinger, F; Smolen, JS.
Extracorporeal photochemotherapy for the treatment of systemic lupus erythematosus. A pilot study.
Arthritis Rheum. 1992; 35(3):319-324
Doi: 10.1002/art.1780350311
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- Co-authors Med Uni Graz
- Graninger Winfried
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- Abstract:
- OBJECTIVE. To investigate the effectiveness and feasibility of extracorporeal photochemotherapy (ECP) in the treatment of an autoimmune disease with known cutaneous photosensitivity. METHODS. Ten patients with systemic lupus erythematosus (SLE) were treated with ECP in an open clinical trial. The efficacy of treatment was analyzed by means of established disease activity scores. RESULTS. Eight patients completed the trial. In 7 of the 8, there was a significant response to the treatment, with no or minor side effects. The clinical activity score in the group of 8 patients decreased from a median of 7 (range 4-9) to a median of 1 (range 0-5) (P less than 0.05). Laboratory abnormalities did not change significantly, but were mild at the outset. CONCLUSION. ECP led to clinical improvement of SLE without side effects. The effectiveness of this method should be investigated further in controlled clinical trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Biopsy -
- Cell Survival - drug effects
- Humans - drug effects
- Hypotension - etiology
- Immunity, Cellular - etiology
- Leukapheresis - etiology
- Lupus Erythematosus, Systemic - drug therapy
- Lymphocytes - cytology
- Methoxsalen - adverse effects
- Middle Aged - adverse effects
- Nausea - chemically induced
- Photochemotherapy - adverse effects
- Pilot Projects - adverse effects
- Skin - pathology
- Ultraviolet Rays - pathology