Medizinische Universität Graz - Research portal
Selected Publication:
Graninger, WB.
Transcriptional overexpression of the proto-oncogene bcl-2 in patients with systemic Lupus erythematosus.
Wien Klin Wochenschr. 1992; 104(7):205-207
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PubMed
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- Leading authors Med Uni Graz
- Graninger Winfried
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- Abstract:
- In systemic Lupus erythematosus (SLE) spontaneous hyperreactivity of the cells of the immune system leads to the production of pathogenic autoantibodies. A hyperproliferative state of lymphocytes is indicated by the increased expression of nuclear oncogenes. We investigated the expression of a putative proto-oncogene, bcl-2, which is responsible for prolonged survival of lymphocytes and protection from programmed cell death. In 19 of 24 patients with SLE an increased concentration of bcl-2 mRNA was found in unstimulated circulating blood lymphocytes. The overexpression of the bcl-2 gene was more pronounced in patients with active SLE. A pathogenic role of increased bcl-2 expression and prolonged survival of autoimmune memory cells in SLE can be hypothesized.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cell Survival - genetics
- Female -
- Gene Expression Regulation - physiology
- Humans -
- Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology
- Lymphocytes - immunology
- Middle Aged -
- Proto-Oncogene Proteins - genetics
- Proto-Oncogene Proteins c-cbl -
- RNA, Messenger - genetics
- Transcription, Genetic - genetics
- Ubiquitin-Protein Ligases -
- Find related publications in this database (Keywords)
- ONCOGENES
- BCL-2
- SYSTEMIC LUPUS ERYTHEMATOSUS