Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hassfeld, W; Steiner, G; Hartmuth, K; Kolarz, G; Scherak, O; Graninger, W; Thumb, N; Smolen, JS.
Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis.
Arthritis Rheum. 1989; 32(12):1515-1520
Doi: 10.1002/anr.1780321204
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- Co-Autor*innen der Med Uni Graz
- Graninger Winfried
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- Abstract:
- Using immunoblot analysis with soluble nuclear extracts from HeLa cells, we identified autoantibodies to an antigen with a molecular weight of approximately 33,000 in 36% of 95 sera from rheumatoid arthritis patients, but in only 1 of 170 controls. The antigen, termed RA33, was resistant to DNase and RNase digestion but sensitive to proteinase K treatment. There was no discernible relation to other autoantibodies. Thus, this newly described autoantibody appears to be highly specific for rheumatoid arthritis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Antinuclear - analysis
- Antibody Specificity - analysis
- Arthritis, Rheumatoid - blood
- Autoantibodies - analysis
- Female - analysis
- Humans - analysis
- Male - analysis
- Middle Aged - analysis
- Molecular Weight - analysis
- Synovial Fluid - immunology