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Selected Publication:
Graninger, WB; Seto, M; Boutain, B; Goldman, P; Korsmeyer, SJ.
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
J Clin Invest. 1987; 80(5):1512-1515
Doi: 10.1172/JCI113235
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- Graninger Winfried
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- Abstract:
- We examined the expression of the Bcl-2 gene at chromosome segment 18q21, that is translocated into the Ig heavy chain gene locus in t(14;18) bearing lymphomas. Bcl-2, while B cell associated, is expressed in a variety of hematopoietic lineages including T cells. Bcl-2 mRNA levels are high during pre-B cell development, the time at which the t(14;18) translocation occurs, but are down regulated with maturation. Like certain other oncogenes, Bcl-2 is quiescent in resting B cells but up-regulated with B cell activation. Mature B cell lymphomas with a t(14;18) have log-folds more mRNA than matched counterparts without the translocation. A sensitive S1 protection assay revealed that all transcripts in t(14;18) B cells were Bcl-2-Ig fusion mRNAs and originated from the translocated allele. Thus, there is a marked deregulation of Bcl-2 when it is introduced into the Ig locus in t(14;18) lymphomas.
- Find related publications in this database (using NLM MeSH Indexing)
- B-Lymphocytes - metabolism
- Cell Differentiation -
- Chromosomes, Human, Pair 14 -
- Chromosomes, Human, Pair 18 -
- Gene Expression Regulation -
- Humans -
- Lymphocyte Activation -
- Lymphocytes - metabolism
- Lymphoma - genetics
- Oncogenes -
- RNA, Messenger - genetics
- T-Lymphocytes - metabolism
- Transcription, Genetic -
- Translocation, Genetic -
- Tumor Cells, Cultured -