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Selected Publication:
Smolen, JS; Bettelheim, P; Köller, U; McDougal, S; Graninger, W; Luger, TA; Knapp, W; Lechner, K.
Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with commercial factor VIII concentrate. Correlation with T cell subset distribution, antibodies to lymphadenopathy-associated or human T lymphotropic virus, and analysis of the cellular basis of the deficiency.
J Clin Invest. 1985; 75(6):1828-1834
Doi: 10.1172/JCI111896
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- Co-authors Med Uni Graz
- Graninger Winfried
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- Abstract:
- 14 patients with hemophilia were studied for the distribution of T cell subsets, the presence of antibody to lymphadenopathy-associated or human T lymphotropic virus type III (LAV/HTLV-III), and their responsiveness in autologous mixed lymphocyte reactions. In addition, mitogen and alloantigen responsiveness and Interleukin-2 production were investigated. Seven patients were found to have low Leu 3a/Leu 2a (T4/T8) ratios; eight patients had antibody to LAV/HTLV-III; and an additional patient had acquired immunodeficiency syndrome. Responsiveness to mitogens and alloantigens as well as Interleukin-2 production were comparable with those of healthy individuals. However, patients with low ratio, many of whom had antibodies to LAV/HTLV-III, had a highly deficient autologous mixed lymphocyte reaction. This reduced response of T cells to autologous non-T cells could not be corrected by elimination of Leu 2a/T8 cells, which indicated that there was a preferential loss of the Leu 3a cell subset(s) which responded to autologous non-T cells. Thus, these patients have a deficiency of intercellular communication within their immune system.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - complications
- Adolescent - complications
- Adult - complications
- Antibodies, Viral - analysis
- Antigens, Differentiation, T-Lymphocyte - analysis
- Antigens, Surface - analysis
- Deltaretrovirus - immunology
- Factor VIII - therapeutic use
- Hemophilia A - complications
- Humans - complications
- Immunologic Deficiency Syndromes - complications
- Interleukin-2 - biosynthesis
- Lymphocyte Culture Test, Mixed - biosynthesis
- Lymphocytes - immunology
- Male - immunology
- T-Lymphocytes - classification