Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Aringer, M; Wintersberger, W; Steiner, CW; Kiener, H; Presterl, E; Jaeger, U; Smolen, JS; Graninger, WB.
High levels of bcl-2 protein in circulating T lymphocytes, but not B lymphocytes, of patients with systemic lupus erythematosus.
Arthritis Rheum. 1994; 37(10):1423-1430 Doi: 10.1002/art.1780371004
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Graninger Winfried
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: OBJECTIVE. Defective regulation of programmed cell death (apoptosis) may play a role in the development of autoimmune diseases, and the proto-oncogene bcl-2 is involved in the control of apoptosis in immunocompetent cells. We therefore wished to investigate the expression of bcl-2 in the peripheral lymphocytes of patients with systemic lupus erythematosus (SLE), a prototypical autoimmune disease. METHODS. Levels of bcl-2 expression in the lymphocytes of patients with SLE and, for comparison, in the lymphocytes of healthy controls and patients with rheumatoid arthritis (RA), systemic bacterial infections, and chronic B cell lymphocytic leukemia were studied by 2-color cytofluorography and RNA analysis. RESULTS. In SLE patients, a significant proportion of T cells expressed increased amounts of bcl-2 protein. By fluorescence-activated cell sorter analysis, bcl-2--enriched lymphocytes were found in the CD45RO+ as well as in the CD45RO-, and also in the CD4+ and CD8+, lymphocyte subpopulations. Mononuclear cells of patients with SLE showed increased amounts of bcl-2 messenger RNA. An increased percentage of strongly bcl-2 positive peripheral T lymphocytes was found in patients with bacterial infections, but not in those with RA. CONCLUSION. Although the occurrence of circulating T lymphocytes with abnormally high bcl-2 expression is not specific for SLE, it is evidence for a dysregulation of lymphocytic programmed cell death in this autoimmune disease.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; B-Lymphocytes - chemistry; Base Sequence -; Female -; Fluorescent Antibody Technique -; Humans -; Lupus Erythematosus, Systemic - blood; Male -; Middle Aged -; Molecular Sequence Data -; Polymerase Chain Reaction -; Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins c-bcl-2 -; RNA, Messenger - analysis; Severity of Illness Index -; T-Lymphocytes - chemistry