Medizinische Universität Graz - Research portal
Selected Publication:
Jaeger, U; Panzer, S; Bartram, C; Haas, O; Volc-Platzer, B; Graninger, W; Geissler, K; Radaszkiewicz, T; Lechner, K.
Autoimmune-thrombocytopenia and SLE in a patient with 5q-anomaly and deletion of the c-fms oncogene.
Am J Hematol. 1994; 45(1):79-80
Doi: 10.1002/ajh.2830450112
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Graninger Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Autoimmune-thrombocytopenia was the striking feature in a patient with typical clinical symptoms of systemic lupus erythematosus (SLE), complement C4 deficiency, and positive lupus serology. However, myelodysplasia was found in the bone marrow and chromosome analysis revealed a deletion of the long arm of chromosome 5 (5q-anomaly), which was confirmed by a hemizygosity for the c-fms oncogene (CSF-1-receptor) on Southern blot. Autoimmune phenomena reported in conjunction with myelodysplastic syndromes (MDS), e.g., an elevation of antinuclear antibodies, are usually regarded as nonspecific. This case report suggests that SLE can occur in patients with MDS and that a concomitant autoimmune-thrombocytopenia may mask the typical signs of the 5q- syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blotting, Southern -
- Chromosomes, Human, Pair 5 -
- Female -
- Gene Deletion -
- Genes, fms -
- Humans -
- Lupus Erythematosus, Systemic - genetics
- Myelodysplastic Syndromes - genetics
- Purpura, Thrombocytopenic, Idiopathic - genetics
- Receptor, Macrophage Colony-Stimulating Factor - genetics
- Find related publications in this database (Keywords)
- MYELODYSPLASTIC SYNDROME
- IMMUNOLOGICAL PHENOMENA
- SLE