Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Knobler, RM; Trautinger, F; Graninger, W; Macheiner, W; Gruenwald, C; Neumann, R; Ramer, W.
Parenteral administration of 8-methoxypsoralen in photopheresis.
J Am Acad Dermatol. 1993; 28(4):580-584
Doi: 10.1016/0190-9622(93)70077-7
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- Co-Autor*innen der Med Uni Graz
- Graninger Winfried
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- Abstract:
- BACKGROUND: Extracorporeal photochemotherapy (EP) is used for the treatment of cutaneous T-cell lymphoma (CTCL), progressive systemic sclerosis (PSS), pemphigus vulgaris, and rheumatoid arthritis. During this procedure, the oral administration of the photoactive drug 8-methoxypsoralen (8-MOP) results in an unpredictable range of serum levels and in side effects limiting its efficacy. OBJECTIVE: To circumvent this limitation, extracorporeally administrable 8-MOP (EX-8-MOP) was developed. It is administered directly to the leukocyte/plasma concentrate in the treatment bag of the EP apparatus before irradiation with UVA light. METHODS: Efficacy, tolerance, and side effects of EX-8-MOP were evaluated in 108 consecutive treatments of 16 patients who had previously been treated with oral 8-MOP (91 treatments). RESULTS: With EX-8-MOP constant drug levels for UV light exposure were obtained; for equivalent levels only a small fraction of the oral dose (1/250 to 1/500) was required with none of the side effects associated with oral 8-MOP. Effective and reproducible inhibition of lymphocyte proliferation and cell viability was attained. No difference in clinical efficacy could be observed. CONCLUSION: EX-8-MOP eliminates the need for premedication and drug level monitoring of 8-MOP and should improve the effectiveness of EP.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Capsules -
- Cell Survival - drug effects
- Chromatography, High Pressure Liquid - drug effects
- Humans - drug effects
- Infusions, Parenteral - drug effects
- Leukapheresis - drug effects
- Lymphocytes - drug effects
- Methoxsalen - administration and dosage
- Nausea - chemically induced
- Photochemotherapy - methods
- Skin Diseases - blood
- Skin Neoplasms - blood
- Vomiting - chemically induced