Medizinische Universität Graz - Research portal
Selected Publication:
Erlacher, L; Wyatt, J; Pflugbeil, S; Köller, M; Ullrich, R; Vogelsang, H; Smolen, JS; Graninger, W.
Sucrose permeability as a marker for NSAID-induced gastroduodenal injury.
Clin Exp Rheumatol. 1998; 16(1): 69-71.
Web of Science
PubMed
Google Scholar
- Leading authors Med Uni Graz
- Graninger Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- OBJECTIVE: To evaluate sucrose permeability as a non-invasive test for the monitoring of upper gastrointestinal mucosal damage (uGMD) in patients treated with NSAIDs. METHODS: 40 patients with non-inflammatory joint pain were enrolled in a prospective study. Before and after 14 days of ibuprofen treatment (3 x 400 mg/day), the rates of urinary sucrose excretion after an oral sucrose load were assessed. Individuals with increased sucrose permeability underwent endoscopy. RESULTS: 8 patients (20%) showed abnormal sucrose permeability before taking any NSAID. In 5/20 patients (25%) who completed 2 weeks of ibuprofen medication, sucrose excretion increased above the normal level. Endoscopic examination and biopsy revealed mild uGMD, but no ulceration in 8/11 (72%) patients with increased permeability to this marker. CONCLUSION: Sucrose permeability testing is a sensitive procedure for research protocols on NSAID-induced gastropathy. Since this test also seems to detect slight and clinically insignificant mucosal damage, however, its use in clinical decision-making regarding gastroprotective medication is limited.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anti-Inflammatory Agents, Non-Steroidal - adverse effects
- Cell Membrane Permeability - adverse effects
- Duodenal Diseases - chemically induced
- Endoscopy, Digestive System - chemically induced
- Female - chemically induced
- Humans - chemically induced
- Ibuprofen - adverse effects
- Male - adverse effects
- Middle Aged - adverse effects
- Predictive Value of Tests - adverse effects
- Rheumatic Diseases - drug therapy
- Stomach Diseases - chemically induced
- Sucrose - diagnostic use
- Find related publications in this database (Keywords)
- sucrose
- NSAID
- gastropathy