Medizinische Universität Graz - Research portal
Selected Publication:
Brunner, M; Greinix, HT; Redlich, K; Knöbl, P; Smolen, J; Leitner, G; Derfler, K; Graninger, W; Kalhs, P; Machold, K.
Autologous blood stem cell transplantation in refractory systemic lupus erythematosus with severe pulmonary impairment: a case report.
Arthritis Rheum. 2002; 46(6):1580-1584
Doi: 10.1002/art.10282
(- Case Report)
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- Co-authors Med Uni Graz
- Graninger Winfried
- Greinix Hildegard
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- Abstract:
- For patients with severe forms of autoimmunity, including systemic lupus erythematosus (SLE), purging autoreactive T cells from the immune repertoire by transplanting autologous hematopoietic stem cells (ASCT) is a therapeutic option. We describe an 18-year-old woman with SLE who had been treated with corticosteroids, azathioprine, cyclophosphamide (CYC), and immunopheresis for 4 years, during which time mechanical ventilation for lupus pneumonitis had been repeatedly required. After the patient was conditioned by administration of CYC and antithymocyte globulin, a total of 8.87 x 10(6) purified CD34+ cells per kg of body weight was infused. Hematopoietic regeneration was observed within 9 days. Twenty-one months after ASCT, the patient continues to be in complete clinical remission, with no signs of SLE-related disease activity and without any immunosuppressive medications. Her pulmonary function has returned to normal. Although a longer followup is required for assessment of the durability of response, the patient's course indicates that ASCT may be a way to reinduce tolerance in patients with SLE.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - therapy
- Pneumonia - etiology Pneumonia - radiography Pneumonia - therapy
- Respiratory Function Tests -
- Tomography, X-Ray Computed -
- Transplantation, Autologous -