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Selected Publication:
Thaler, J; Gastl, G; Fluckinger, T; Niederwieser, D; Huber, H; Seewann, H; Sill, H; Lang, A; Falk, M; Duba, C; Utermann, G; Kühr, T; Aulitzky, W; Huber, C.
Interferon alpha-2c therapy of patients with chronic myelogenous leukemia: long-term results of a multicenter phase-II study. Austrian Biological Response Modifier (BRM) Study Group.
Ann Hematol. 1996; 72(6):349-355
Doi: 10.1007/s002770050185
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Sill Heinz
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- Abstract:
- In a prospective multicenter phase-II trial 80 patients with Philadelphia (Ph)-positive chronic myelogenous leukemia (CML) were treated with recombinant interferon (IFN) alpha-2c, administered subcutaneously at an absolute dose of 3.5 megaunits (MU)/day. Complete hematological remission was achieved in 29 (39%) and partial hematological remission in 26 (35%) of the 74 patients evaluable for response. Major cytogenetic responses were observed in ten (13%) and minor cytogenetic responses in 11 patients (15%). Median duration of cytogenetic response was 33 months (range, 2-90); relapses were seen in all of the 11 patients with minor and in three of the ten patients with major cytogenetic responses. Median survival estimates for pretreated (n = 19) and untreated (n = 58) patients were 51 months (95% confidence interval [CI], 30-72) and 77 months (95% CI, 43-111), and the survival probabilities at 5 years were 45% and 54% for the two groups, respectively. Hematological response after 3 months of treatment demonstrated a clear-cut discriminative capacity with 5-year survival probabilities of 100%, 67% and 24% for patients achieving CHR (n = 6), PHR (n = 34), and less than PHR (n = 35), respectively. Landmark analysis at 12, 18, and 24 months after start of IFN therapy and an analysis treating time to cytogenetic response as a time-dependent covariate showed that cytogenetic response was associated with longer survival. The impact of a low-dose IFN regimen on survival in CML patients is unclear and requires further clarification by randomized clinical trials. Early hematological and cytogenetic response to IFN-alpha treatment identifies patients with a favorable long-term prognosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antineoplastic Agents - therapeutic use
- Child - therapeutic use
- Cytogenetics - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Interferon Type I, Recombinant - therapeutic use
- Leukemia, Myeloid, Chronic - pathology
- Longitudinal Studies - pathology
- Lymphocyte Activation - pathology
- Male - pathology
- Middle Aged - pathology
- Prospective Studies - pathology
- Remission Induction - pathology
- Risk Factors - pathology
- Survival Analysis - pathology
- Find related publications in this database (Keywords)
- CML
- interferon alpha
- cytogenetic response