Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Maltaris, T; Scalera, F; Schlembach, D; Hoffmann, I; Mueller, A; Binder, H; Goecke, T; Hothorn, T; Schild, RL; Beckmann, MW; Dittrich, R.
Increased uterine arterial pressure and contractility of perfused swine uterus after treatment with serum from pre-eclamptic women and endothelin-1.
Clin Sci (Lond). 2005; 109(2):209-215
Doi: 10.1042/CS20040340
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- Co-Autor*innen der Med Uni Graz
- Schlembach Dietmar
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- Abstract:
- The present study was designed to examine the effects of ET-1 (endothelin-1) and serum from PE (pre-eclamptic), HP (healthy pregnant) and HNP (healthy non-pregnant) women on uterine arterial perfusion pressure and uterine contractility. Swine uteri (n = 25) were perfused for a period of up to 11 h, with the aim being to preserve a viable organ. Various concentrations of ET-1 as well as serum from PE, HP and HNP women (n = 10 per group) were administered to the perfused swine uteri and IUP (intrauterine pressure) and IAP (intra-arterial pressure) were recorded. ET-1 produced dose-dependent increases in IUP and IAP. The ET-1 concentration in serum was higher in serum from PE women than in HP and HNP women (P > 0.05). Administration of all serum samples had a contractile effect on the swine uterus, with the greatest effect being seen in HNP women (12.8 +/- 5.3 mmHg), followed by PE (9.06 +/- 4.2 mmHg) and HP (6.1 +/- 4.1 mmHg) women. Statistically significant differences were observed between HNP and PE women (P = 0.048), and PE and HP women (P = 0.021). Increases in IAP following administration of serum from PE women (48.8 +/- 20.0 mmHg) were significantly higher (P = 0.024) compared with the effect of serum from HP women (28.4 +/- 13.7 mmHg). In conclusion, the findings show that serum from PE women has significant vasoconstrictive and oxytocic effects compared with serum from HP women. In pre-eclampsia, the balance between vasorelaxing and vasoactive substances is disturbed.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arteries -
- Blood Pressure - drug effects
- Endothelin-1 - pharmacology
- Female - pharmacology
- Humans - pharmacology
- Organ Culture Techniques - pharmacology
- Perfusion - pharmacology
- Pre-Eclampsia - blood
- Pregnancy - blood
- Swine - blood
- Uterine Contraction - drug effects
- Uterus - blood supply
- Vasomotor System - physiopathology
- Find related publications in this database (Keywords)
- arterial pressure
- enclothelin-1 (ET-1)
- pre-eclampsia
- pregnancy
- uterus