Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wenzl, H; Petritsch, W; Reicht, G; Eherer, A; Krejs, GJ.
Cyclosporin for the treatment of severe ulcerative colitis.
Z Gastroenterol. 1994; 32(3):137-140
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Eherer Andreas
- Krejs Günter Josef
- Petritsch Wolfgang
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- Abstract:
- The effect of cyclosporin was evaluated in six patients with severe ulcerative colitis not responding to at least 8 days of standard therapy with intravenous corticosteroids. Cyclosporin (5-7.5 mg/kg/day intravenously) was added while steroid therapy was continued. Five of 6 patients responded after a mean of 7 days and colectomy was not necessary. After 4 weeks three patients achieved clinical remission or had mild symptoms and were weaned from cyclosporin and corticosteroids without exacerbation within the next 7-15 months. Two patients improved and they were put on oral cyclosporin. One of them relapsed after 2 weeks and then responded to high dose corticosteroids. This patient is doing well at 8 months of followup on azathioprine and steroids. One patient stopped oral cyclosporin after 3 months abruptly and then had a relapse. He subsequently improved while refusing any medical therapy. Side effects of cyclosporin occurred in 2 patients but were mild and self limited and did not necessitate discontinuation of the drug. Cyclosporin appears to be effective in a large portion of patients with severe ulcerative colitis who failed to improve on corticosteroids and in whom colectomy would otherwise be considered.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Colitis, Ulcerative - drug therapy
- Cyclosporine - adverse effects Cyclosporine - therapeutic use
- Dose-Response Relationship, Drug -
- Female -
- Humans -
- Infusions, Intravenous -
- Male -
- Middle Aged -
- Prospective Studies -
- Recurrence -
- Find related publications in this database (Keywords)
- Cyclosporine
- Ulcerative Colitis
- Immunosuppression
- Inflammatory Bowel Disease