Medizinische Universität Graz - Research portal
Selected Publication:
Malle, E; Leis, HJ; Steinmetz, A; Paschke, E; Hoefler, G.
Cyclooxygenase pathway in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin.
CLIN CHIM ACTA. 1993; 217(2): 205-212.
Doi: 10.1016/0009-8981(93)90167-3
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Malle Ernst
- Co-authors Med Uni Graz
- Höfler Gerald
- Leis Hans-Joerg
- Paschke Eduard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cyclooxygenase metabolism was studied in fibroblasts from patients with metabolic disorders of peroxisomal origin (adrenomyeloneuropathy, X-linked adrenoleukodystrophy, cerebrohepatorenal syndrome of Zellweger and rhizomelic chondrodysplasia punctata). In response to arachidonic acid (6.25-100 microM) or calcium ionophore A23187 (2.5-20 microM) prostaglandin E2 and 6-keto-prostaglandin F1 alpha are the main cyclooxygenase metabolites formed. No formation of thromboxane B2 or 2,3-dinor-thromboxane B2 was found. Apparently due to the heterogeneous nature of peroxisomal disorders no uniform pattern of cyclooxygenase metabolism and eicosanoid concentrations in cell lines from patients with peroxisomal defects was found.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Ketoprostaglandin F1 alpha - biosynthesis
- Adrenoleukodystrophy - enzymology
- Cells, Cultured - enzymology
- Chondrodysplasia Punctata - enzymology
- Dinoprostone - biosynthesis
- Fibroblasts - enzymology
- Humans - enzymology
- Linkage (Genetics) - enzymology
- Microbodies - metabolism
- Prostaglandin-Endoperoxide Synthases - metabolism
- Skin - cytology
- X Chromosome - cytology
- Zellweger Syndrome - enzymology
- Find related publications in this database (Keywords)
- Peroxisomal Disease Fibroblasts
- Eicosanoids
- Arachidonic Acid Metabolism
- Gas Chromatography Mass Spectrometry