Medizinische Universität Graz - Research portal
Selected Publication:
Varga, EM; Jacobson, MR; Till, SJ; Masuyama, K; O'Brien, F; Rak, S; Lund, V; Scadding, GK; Hamid, QA; Durham, SR.
Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis.
Allergy. 1999; 54(4): 338-345.
Doi: 10.1034/j.1398-9995.1999.00957.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Varga Eva-Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells. METHODS: Nasal biopsies from perennial allergic rhinitis patients and controls were analysed by immunocytochemistry for different cell populations and in situ hybridization for cytokine mRNA-expressing cells. RESULTS: Perennial allergic rhinitis was associated with increased numbers of submucosal CD3+ T cells (P=0.05), EG2+ activated eosinophils (P=0.01), and CD68+ macrophages (P=0.01) compared to controls. Epithelial, but not submucosal, tryptase-positive mast cells were also elevated in rhinitics compared to controls (P=0.01). The numbers of cells expressing interleukin (IL)-5 were higher (P=0.01) and the numbers of cells expressing IL-2 were lower (P=0.04) in rhinitic patients than controls. There were no significant differences for either IL-4 or interferon-gamma between the groups. CONCLUSIONS: Perennial allergic rhinitis is characterized by mast-cell migration into the epithelium; submucosal infiltration by T cells, eosinophils, and macrophages; and an imbalance in local T-cell cytokine production in favour of enhanced IL-5 and reduced IL-2 expression.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, CD3 - immunology
- Cytokines - metabolism
- Eosinophils - immunology
- Female - immunology
- Humans - immunology
- Immunohistochemistry - immunology
- In Situ Hybridization - immunology
- Macrophages - immunology
- Male - immunology
- Mast Cells - immunology
- Nasal Mucosa - immunology
- RNA, Messenger - metabolism
- Receptors, Interleukin-2 - immunology
- Rhinitis, Allergic, Perennial - immunology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- cytokines
- eosinophils
- perennial allergic rhinitis
- T cells